Drug-Nutrient Interactions

OMEPRAZOLE Also indexed as: Losec®, Prilosec®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including Omeprazole, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Vitamin B12 Omeprazole interferes with the absorption of vitamin B12 from food (though not from supplements) in some studies. The fall in vitamin B12 status may result from the decrease in stomach acid required for vitamin B12 absorption from food, caused by the drug. However, all those taking Omeprazole need to either supplement with vitamin B12 or have their vitamin B12 status checked.

Ranitidine Also indexed as: Zantac®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including ranitidine, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Iron Stomach acid may facilitate iron absorption. Ranitidine reduces stomach acid and is associated with decreased dietary iron absorption. Iron levels in the blood should be checked with lab tests.

Magnesium In healthy volunteers, a magnesium antacid, taken with ranitidine, decreased ranitidine absorption by 20%–25%. This interaction can be avoided by taking ranitidine two hours before or after any magnesium-containing antacids, including magnesium in vitamin/mineral supplements.

Vitamin B12 Stomach acid is needed to release vitamin B12 from food so it can be absorbed by the body. Ranitidine reduces stomach acid and is associated with decreased dietary vitamin B12 absorption. The vitamin B12 found in supplements is available to the body without the need for stomach acid. Lab tests can determine vitamin B12 levels.

Interactions with Other Compounds

Tobacco (Nicotiana species) A study of 18 healthy people found smoking decreased the acid blocking effects of Ranitidine.

© Vicki Martin, Nutrition and Herbal Technical Consultant, Healtheries of New Zealand Limited. Used with permission.

  • What support (other than peer) is available through GRSN?

  • Can someone please tell me if omeprazole gets worse before it gets better? Follow up app isn't for 5 more weeks and after one week on this I am at my wits end with the ZERO sleep! Son is 14mo and his sleeping is so very much worse which I didn't even think was actually possible but just wondering if I should stop it or keep going.

  • https://whanau.skip.org.nz/behaviours/not-sleeping/

  • Hi there, does anyone know the research on whether losec as a single dose or split dose is better for infants?

  • Sarah has a question about Neocate and Elecare. Have a look at the visitor posts to page. No advice, just experiences please.

  • Has Anyone tried both neocate and elecare? Any difference?

  • Worth a look https://www.facebook.com/babocush/posts/1887748414848173

  • Hi,just wondering if anyone has a lactation consultant in Auckland that they would recommend. I have a very fast flow and birth my first child, and now my second (9 days old) have had issues with it. My first had silent reflux I believe,and now my second's behavior after feeding is following the exact same path. I'd like to see if there's anything other than laying back whilst feeding that I can do to help ease irritation that seems to be occurring. Thanks in advance!

  • This chat with Plunket New Zealand should be interesting.

  • My three month old (baby two with reflux and seems to have cmpi like my eldest) is really struggling. Has started on losec three weeks ago, is constipated (never went often anyway), and now trying to get him onto neocate (previously breastfed with ebm top ups but can't keep pumping and stressing about supply). Am trying to sweeten the formula but he's not keen so far. Anyone share experiences of getting babe onto it? Anyone for whom it actually took 15 tried to take it like website suggests? Eldest was no bother so this is new to me. Thanks :/

  • Just wondering has anyone dealing with reflux had an issue with constipation too. Our LO has had alot of problems with constipation since starting solids beginning of Jan. We've tried a couple laxatives & have had to resort to suppository's.

  • GRSNNZ would like to highlight our Site Guidelines which also cover this Facebook Page after some recent concerns. Please read. In particular: As the moderators, GRSNNZ reserves the right to remove or edit any posts: - that recommend another medication as being better or to treat conditions that it is not indicated for - that give medical advice --------------------------------------------------------------------- You are all great supports to each other. Please carry on doing this. These guidelines are to keep this Page a safe and happy place.

  • 💜💙💚💛💖

  • If you are feeling stressed these tips might be a help.

  • Hey all, I have a hard time latching my three month old, in particular on one breast. He will repeatedly pull off and turn his head to the side. Does it on the other breast too, turning head in opposite direction. Do you think this is related to reflux or something else? Sometimes think he's just not hungry but can be hours since he last ate. His weight gain has been slow. He's on lose c now. Ta for any insight!!

  • My 8 week old has suspected silent reflux, he shows all the signs, feeds non stop, putting on huge amounts of weight, will not sleep unless being upright and if he is laid down will wake after 10 minutes screaming, pulls off the breast constantly and a really clingy, high maintenance baby. I've been given gaviscon but struggling to get him to take it, I've tried in s bottle of expressed milk but were struggling to get her to take a bottle, tried it in a syringe with water but he gags, any suggestions, I'm one exhausted mumma with two toddlers to look after aswel

  • Does anyone else get so sick from this?? I have tried every tablet and nothing helps to the point I have lost so much weight and now may need a feeding tube 😴

  • #tautoko

  • Question.... my midwife suggested my baby has silent reflux and we have been on infant gaviscon but wondering if we have the right diagnosis??! How do we go about getting a proper diagnosis? Thanks 😀

  • Tips to encourage early speech & language development that only take a MOMENT in busy schedules.

  • Moving on to solids soon? Maybe you would like to join Plunket New Zealand for their chat.

  • Remember with a baby that cries a lot you need to look after you too, and sometimes you may need to put them down and walk away.