Drug-Nutrient Interactions

OMEPRAZOLE Also indexed as: Losec®, Prilosec®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including Omeprazole, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Vitamin B12 Omeprazole interferes with the absorption of vitamin B12 from food (though not from supplements) in some studies. The fall in vitamin B12 status may result from the decrease in stomach acid required for vitamin B12 absorption from food, caused by the drug. However, all those taking Omeprazole need to either supplement with vitamin B12 or have their vitamin B12 status checked.

Ranitidine Also indexed as: Zantac®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including ranitidine, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Iron Stomach acid may facilitate iron absorption. Ranitidine reduces stomach acid and is associated with decreased dietary iron absorption. Iron levels in the blood should be checked with lab tests.

Magnesium In healthy volunteers, a magnesium antacid, taken with ranitidine, decreased ranitidine absorption by 20%–25%. This interaction can be avoided by taking ranitidine two hours before or after any magnesium-containing antacids, including magnesium in vitamin/mineral supplements.

Vitamin B12 Stomach acid is needed to release vitamin B12 from food so it can be absorbed by the body. Ranitidine reduces stomach acid and is associated with decreased dietary vitamin B12 absorption. The vitamin B12 found in supplements is available to the body without the need for stomach acid. Lab tests can determine vitamin B12 levels.

Interactions with Other Compounds

Tobacco (Nicotiana species) A study of 18 healthy people found smoking decreased the acid blocking effects of Ranitidine.

© Vicki Martin, Nutrition and Herbal Technical Consultant, Healtheries of New Zealand Limited. Used with permission.

  • Just for some fun. You have to watch the clip.

    Thinking back two years prior to pregnancy, this couple recalls how they thought they had everything about parenting all figured out. But they quickly realized all of their aspirations were not very realistic when their precious little one was born into the world.

  • Gastric Reflux Support Network NZ shared Judy Arnold - Infant and child Consultant's photo.

    It is about time for another Coffee together and to ask Questions Thursday morning, 9.30-11. Looking forward to catching up.

  • Just wondering - is gaviscon like a fast acting relief - like for that feed only- or is it longer lasting ?

    I haven't used gaviscon for 3 days and my 10 week old has been good for 3 days so thought maybe he was getting a bit better - but then tonight spewed up quite a bit. Is that because the gaviscon was still working in his system and now has worn off ? Or does it have a shorter term effect ?

    We have also just started trying formula. 50ml yesterday and today and it was after that he spewed- so also wanting to rule out the fact that it's the gaviscon wearing off...to see if the formula is making him spew.

    I'm pretty sure he's reacting to the formula but just curious how long gaviscon relief works also.

  • Gastric Reflux Support Network NZ shared Hope For The Broken Hearted's photo.

  • Gastric Reflux Support Network NZ shared Interstitial Cystitis Association's photo.

  • Gastric Reflux Support Network NZ shared Patient's photo.

    #sleep

  • Empowering families of people with disabilities and health impairments through support and information.

  • Hi there, my daughter has been on omeprozole granules (5mg, twice daily) since 6 weeks old. I've talked to our GP about how and when to wean, his advice was to go cold turkey "whenever we felt like it"..!

    I'm looking for some advice from other families on how they went about weaning - Would like to take a gentle path.
    Are there signs of readiness?
    What age did you start?
    Did you drop one dose and see if there was any effect before fully weaning?
    Or is cold turkey the right thing to do, after all?

    Thanks.

  • Hi all,
    Does anyone know if its okay to mix kiwiherb stuff with losec to mask the taste if you stick to the correct dosages? Eg .5ml each of kids calm, echinature, and chest syrup mixed with 3.8ml of losec?

  • 10 day old baby showing signs of reflux already. Similar to his brother (who is now 22months).
    He has the "breath that smells like stomach acid", looks like he's got a bad taste in his mouth, the "cottage cheese" spit up at times and obviously a very sore tummy after feeds.
    I am babywearing to keep him upright which is helping.

    I suppose what I'm asking is at what point do I go to gp and ask for a paed referral? My husband says don't go looking for trouble until it becomes a much more obvious issue.

  • Can anyone in the Wellington area recommend a good doctor with an understanding of allergies/ intolerances? I'm convinced our doctor doesn't get it! My poor bubba needs a formula top up and is intolerant to diary protein and soy. The doctor wants to start solids but he is only 4 months, I want to leave it until 6 as there is a family history of food intolerances.

  • Gastric Reflux Support Network NZ shared Plunket New Zealand's event.

    Join our PlunketLine Nurse Carla, PlunketLine Advisor Elaine & National SKIP Advisor Regan to chat about Baby Sleep (12 months and under). Post any questions you have below or private message us and we'll be sure to answer these during our chat. If we missed your question or didn't get to it we'll come back to you in the next 24/48 hours. You can check the chat out here: https://www.facebook.com/PlunketNZ/photos/a.367839658272.194714.176947128272/10153679203903273/?type=1&theater if you need any urgent support or advice you can call PlunketLine anytime - 0800 933 922

  • New Membership Form for the Gastric Reflux Support Network NZ - but same address and similar details required: http://www.reflux.cryingoverspiltmilk.co.nz/grsnnz-membership-confidentiality-agreement-form/

    Please let me know if there are any problems, but I have tested it - and besides the WordPress Plugin insisting on US format for DOB...it was all good. :-)

    Gastric Reflux Support Network NZ for Parents of Infants & Children Charitable Trust Membership & Confidentiality Agreement Form First Name: Last Name: Email Address: Street Address: City/Town: Area: Auckland Canterbury Gisborne Hawkes Bay Marlborough Nelson Northland Otago Southland Taranaki...

  • I've just taken the Membership form offline for a moment whilst I switch it over to a more stable one - I hope. It should be back up within half an hour. I'll let you know!

  • I have a 11 month old who will be 1 in a weeks times who has silent reflux. Gaviscon seems to work for him at them moment however I am looking at reducing the number of bottles he has a day. I was therefore wondering if anyone had any ideas on how to get the gaviscon in to as he current has four doses a day?

  • I have an 18 month old with silent reflux. It seems to flare up dramatically when she is teething. She can wake up to 10 times in a night! I am still breastfeeding and although this is good for her as it helps to comfort her I get very little sleep. I co-sleep so I at least can doze while she's latched. When the reflux is at its worst she gets very angry and lashes out, often banging her head on the ground. It's heartbreaking to watch and when she is in that state she doesn't want to be cuddled. I'm finding it so emotionally challenging as she is generally a happy, giggly, cheeky little girl in between times.
    She was so bad last week I was in full meltdown mode.
    She has had this since birth, I've always had a dairy free diet and from about 6 weeks old I took out dairy,soy, added probiotics and started her at the osteopath also. This helped heaps and at one point she was sleeping 6 hour stints at night. Then at 12weeks old it came back and has never left and I would say the last couple of months is the worst it's ever been. I've upped the probiotics and added other probiotic foods and am taking out acidic foods as much as possible. She has been a little better the last 3 days so hoping she'll keep improving.
    Has anyone had good results with osteo or similar at this age? I'm wondering if it's worth trying that again.
    I also want to know if people have had success with medications because I read forums online and it seems like only approximately(total estimation)
    2/10 people will write that it really helped them so I don't want to pump her full of things if there's not a good chance of it even working. What are your experiences?
    Help! And thanks in advance 😊

  • There are two new posts to the page if anyone would like to help by sharing their experiences.

  • Hi There I am looking for support for a toddler with reflux. She had terrible silent reflux as a baby and then we thought she had grown out of it by 1ish. Then she has been rediagnosed with it age 2 years one month - after countless ENT problems (She has grommets and has had her tonsils and adenoids removed) and constant constipation. The medication is starting to kick in but she is so upset and so angry all the time (also partly because she is a toddler). Any tips people have to soothe her and help her not be afraid of sleeping/ lying down much appreciated, We are also considering reintroducing her dummy as it worked so well last time, but are conflicted about wether it is a terrible idea or not.Thanks

  • For those dealing with a silent refluxer, what are the symptoms you've noticed? We've been treating my 9 month old for this but never had much success which makes me second guess if that's what the problem is :/ she wakes within an hour of going down at night (if we get her down!), won't settle until around midnight, sleep during the day is never guaranteed and now since starting solids she wakes very frequently dumb the night with what looks like either sore tummy or wind pain. Sound like anyone else's baby?

  • Gastric Reflux Support Network NZ shared their note.

    A reminder please when you are replying to messages.

    Please do not give advice on dosages, advise families to give medications in two dosages when they were told to give them once daily by the prescriber or vice versa, or give direct advice on medications, formulas etc.

    It is perfectly fine to share your experiences as long as you do not discuss dosages of medications or mention health professionals etc.

    We love you chatting and supporting each other so please continue to do this, but keep it safe and non-medical.

  • Gastric Reflux Support Network NZ published a note.

  • Gastric Reflux Support Network NZ published a note.

  • Hi Team. My now 3month old has been on Losec for quite sometime now and we had a different chemist make up the liquid and it looked different to out usual dose. Well he now seems like he is back to that child he was before we started on it. I have been back to the old chemist to get it better batch...how long will it take to kick back in,if it has gone out of his system? Cheers. Very exhausted mum

  • Emma has asked a question.

  • Can anyone help us? We have an almost 8 month old she's on Pepti jr, omeprazole and gaviscon. The last 2 weeks have been not very fun for us. She goes off to sleep nicely at 6.30-7 then ban at 9.30-10 inconsolable crying. Her reflux through the day is also much worse. We give losec in the morning and gaviscon with her bottle before bed but not at other feeds because it made her constipated. She's not interested in crawling and rolling anymore because she gets a lot of acid coming up and just wants to stand all the time. She is on a variety of solids is there anything I shouldn't give her because it makes reflux worse? We thought about taking out citrus peaches and apricots?? Too make everything so much more fun she is teething just got her first tooth yesterday ... Any advice much appreciated we would just like some sleep :-(