Drug-Nutrient Interactions

OMEPRAZOLE Also indexed as: Losec®, Prilosec®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including Omeprazole, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Vitamin B12 Omeprazole interferes with the absorption of vitamin B12 from food (though not from supplements) in some studies. The fall in vitamin B12 status may result from the decrease in stomach acid required for vitamin B12 absorption from food, caused by the drug. However, all those taking Omeprazole need to either supplement with vitamin B12 or have their vitamin B12 status checked.

Ranitidine Also indexed as: Zantac®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including ranitidine, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Iron Stomach acid may facilitate iron absorption. Ranitidine reduces stomach acid and is associated with decreased dietary iron absorption. Iron levels in the blood should be checked with lab tests.

Magnesium In healthy volunteers, a magnesium antacid, taken with ranitidine, decreased ranitidine absorption by 20%–25%. This interaction can be avoided by taking ranitidine two hours before or after any magnesium-containing antacids, including magnesium in vitamin/mineral supplements.

Vitamin B12 Stomach acid is needed to release vitamin B12 from food so it can be absorbed by the body. Ranitidine reduces stomach acid and is associated with decreased dietary vitamin B12 absorption. The vitamin B12 found in supplements is available to the body without the need for stomach acid. Lab tests can determine vitamin B12 levels.

Interactions with Other Compounds

Tobacco (Nicotiana species) A study of 18 healthy people found smoking decreased the acid blocking effects of Ranitidine.

© Vicki Martin, Nutrition and Herbal Technical Consultant, Healtheries of New Zealand Limited. Used with permission.

  • Gastric Reflux Support Network NZ shared Developmental Coordination Disorder (Dyspraxia) & Dyslexia Support's photo.

    Someone just liked this that we shared back in 2014. I think it is time to share it again. #gastricreflux

  • Gastric Reflux Support Network NZ added a new photo.

  • My 17 month old son has just been put on ranitadine. The pharmacist said it needs to be away from foods with iron and calcium. He needs it 3 times a day and im insure how to do this around the restrictions. How have others done it?

  • After advice/recommendations about private paediatricians. We are in the Waikato and are desperate to see someone privately about our four month old who suffers terribly with reflux. Happy to travel (I.e. To Auckland) and don't care what it costs. We really just need to get him proper help. I can't stand to see him in such excruciating pain every feed (and most of the time in between feeds!)

  • Gastric Reflux Support Network NZ added a new photo.

  • My 3.5 yr old daughter has terrible reflux blisters in her throat and at 8 months old had a fundoplication which resulted in a pitched nerve now her reflux is back don't know what to do

  • It's Oral Health Month and Plunket shared this article in their recent newsletter: http://www.plunket.org.nz/your-child/1-2-years/health-and-daily-care/10-things-you-need-to-know-about-children-s-teeth/ To add to this, did you know that some children's toothpastes do not have the recommended amount of fluoride in them?

  • Had anyone had any experience of their child having hiccups whilst asleep? Please see our visitor posts.

  • My 2.5 year old appears to be hiccuping in his sleep. Hasn't done this in years. Was feeling he'd had too much dairy building up. Anyone else get this? It's so weird he seems totally asleep....

  • Isn't this the cutest baby ever? One of our Trustees has been amazing with sharing her photos.

  • Bec has posted a message to the page - look under visitor posts - after having weaned her child off medication. Does anyone else who has done this have wise words to share?

  • Hi. My son is just over 18months. I slowly weaned him off his reflux medication. Wondering what are symptoms to look out for to know if he needs to go back on medication. He seemed fine while weaning. But now he wakes during the night, has hiccups regularly plus a few other symptoms. I'm just not sure if it's reflux or just the cold months. Any advice would be fantastic. Thanks!

  • First in a series from our recent slideshow. :-)

  • Hi - has anyone gone private for a gastroscopy and if so who did you use? I stupidly cancelled ours at the start of the year when I felt things were improving (only lasted 2 weeks!) they didn't take us off the list but they pushed us to the back of the list and to date we have still not even been given an indication of time. We have health care but the paediatrician at the hospital had originally said the public system was the best avenue as the person doing it is a gastroenterologist and would have the most qualification on what they are looking at/for. Would love to hear from anyone else that went private / who through and how did they find it?

  • Gastric Reflux Support Network NZ shared Inspiring and Positive Quotes's photo.

  • So we have tried losec but our 7 wo daughter has got worse, went back to the doc who told us to take her off it now, so what now? He wants us to try nasel drops for a week to clear out her nasal passage. I assume this rules out reflux as such as points more to severe wind? Has anyone dealt with losec not helping them/making the problem worse? We burp her plenty and often get wind but the second she lays down she screams the house down. If we are lucky her and us get 3 hrs sleep over a 24hr period, I'm surprised by the doc how relaxed they are about it when it's mentally crippling us both and the lack of sleep for her can't be doing much for her.

  • For Canterbury families:

  • Does anyone know if a baby can have losec and infacol? Not at the same time but during the same day.

  • Hi I was just wondering if there is a support group or page on Facebook to chat with other people? Thanks in advance.

  • #canvacup #gastricreflux #gor #gord #infant #baby #gastricrefluxsupportnetworknz #cryingoverspiltmilk #child #family #reflux #tautoko #tamariki #whanau

  • Gastric Reflux Support Network NZ shared David Wolfe's video.

  • Do you use screens for distraction and have sleep issues with your child? It might be a good idea to not use them for an hour before bed time at night. It could also pay to explore lighting in the room for an hour before bed, and in the bed room during the night and for any night time wakings. Even digital clocks and nightlights are too bright for some.

  • Gastric Reflux Support Network NZ shared Purple Clover's photo.

    ... However, it is essential to have some "you" time. Even just 5 minutes for half a cup of tea. ;-)

  • Gastric Reflux Support Network NZ shared Brainwave Trust Aotearoa's photo.

  • Sorry to anyone who has tried to join using the Join GRSNNZ tab on Facebook. I just realised it wasn't connected to MailChimp. All sorted now. The alternative and probably better way of joining though is to go to: http://www.reflux.cryingoverspiltmilk.co.nz/grsnnz-membership-confidentiality-agreement-form/