Drug-Nutrient Interactions

OMEPRAZOLE Also indexed as: Losec®, Prilosec®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including Omeprazole, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Vitamin B12 Omeprazole interferes with the absorption of vitamin B12 from food (though not from supplements) in some studies. The fall in vitamin B12 status may result from the decrease in stomach acid required for vitamin B12 absorption from food, caused by the drug. However, all those taking Omeprazole need to either supplement with vitamin B12 or have their vitamin B12 status checked.

Ranitidine Also indexed as: Zantac®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including ranitidine, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Iron Stomach acid may facilitate iron absorption. Ranitidine reduces stomach acid and is associated with decreased dietary iron absorption. Iron levels in the blood should be checked with lab tests.

Magnesium In healthy volunteers, a magnesium antacid, taken with ranitidine, decreased ranitidine absorption by 20%–25%. This interaction can be avoided by taking ranitidine two hours before or after any magnesium-containing antacids, including magnesium in vitamin/mineral supplements.

Vitamin B12 Stomach acid is needed to release vitamin B12 from food so it can be absorbed by the body. Ranitidine reduces stomach acid and is associated with decreased dietary vitamin B12 absorption. The vitamin B12 found in supplements is available to the body without the need for stomach acid. Lab tests can determine vitamin B12 levels.

Interactions with Other Compounds

Tobacco (Nicotiana species) A study of 18 healthy people found smoking decreased the acid blocking effects of Ranitidine.

Cisapride Also indexed as: Propulsid®

Interactions with Foods and Other Compounds

Alcohol Alcohol consumption interferes with Cisapride therapy.

Tobacco Smoking interferes with Cisapride therapy.

© Vicki Martin, Nutrition and Herbal Technical Consultant, Healtheries of New Zealand Limited. Used with permission.

  • As per my post yesterday, our membership form and newsletter archive for members is now available again. Please consider joining Gastric Reflux Support Network NZ for Parents of Infants and Children Charitable Trust for access to our Newsletters and Private Local and National Support Networks: http://www.reflux.cryingoverspiltmilk.co.nz/grsnnz-membership-confidentiality-agreement-form/ Membership is free, and this gives you opportunities to discuss gastric reflux related issues with others in a safe and confidential setting. Thanks to one of our amazing webhosts http://www.webmad.co.nz/ for the smooth change-over.

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  • A question please -my daughter has twin girls aged 3 weeks.They were premature born at 35 weeks 3 days.One of them is fine breastfed and sleep.However the other one grunts and groans,pulls her legs up and sometimes cries after each feed.She does not settle well at all.Could this be reflux or what.I know it's early days but my daughter is exhausted!!Any suggestions would be great.Thanks

  • I have a question for mothers who have tried feed thickner. Can constipation occur when using this? I have checked the karicare website but does not state any side effects.

  • I have removed the recent video to our page on how to give Losec mups that was shared by someone. These are not available in NZ.

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  • My 10 week old son is in starship due to heart condition. His omeprizol has just been doubled to try and ease his discomfort with reflux. He is now on twice daily but a nurse said she had heard it was more effective given as a single dose? What are the advantages and disadvantages of a single dose? Sometimes the doctors listen to me and sometimes they dont so id need to have my facts straight if wanting them to change it. He has his omeproxol via ng and gaviscon mixed with pepti junior

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  • My baby is 10weeks (5weeks corrected) and can not sleep on her back at all since this has her coughing and spluttering when not just straight up projectile vomiting. It seems to be worse now she is on thickened formula (alongside omaprozole) esp at night it's like she can't actually spit up the feed anymore (or multiple hours later) as its thicker and therefore she stays choking on it. Does anyone have any nighttime tips it scares me

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  • Hi everyone. I have my second reflux baby (lucky me). She's nine weeks old, spills at least four times per feed, enough to warrant a full change of clothes! She's been on omeprazole (cot also raised) since 5 weeks of age and she's a lovely settled baby now. But, my question for you other parents is how do you handle night feeds? Keely will be lovely relaxed and settled, even asleep and then the spilling starts when she's back in bed. This keeps us up for an hour post feed including changing clothes, cloths under her head etc and of course re settling an over tired baby. I'm a bit rusty. What sort of night feed routine do you follow?

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