Drug-Nutrient Interactions

OMEPRAZOLE Also indexed as: Losec®, Prilosec®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including Omeprazole, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Vitamin B12 Omeprazole interferes with the absorption of vitamin B12 from food (though not from supplements) in some studies. The fall in vitamin B12 status may result from the decrease in stomach acid required for vitamin B12 absorption from food, caused by the drug. However, all those taking Omeprazole need to either supplement with vitamin B12 or have their vitamin B12 status checked.

Ranitidine Also indexed as: Zantac®

Interactions with Nutritional Supplements

Folic acid Folic acid is needed by the body to utilize vitamin B12. Antacids, including ranitidine, inhibit folic acid absorption. Those taking antacids are advised to supplement with folic acid.

Iron Stomach acid may facilitate iron absorption. Ranitidine reduces stomach acid and is associated with decreased dietary iron absorption. Iron levels in the blood should be checked with lab tests.

Magnesium In healthy volunteers, a magnesium antacid, taken with ranitidine, decreased ranitidine absorption by 20%–25%. This interaction can be avoided by taking ranitidine two hours before or after any magnesium-containing antacids, including magnesium in vitamin/mineral supplements.

Vitamin B12 Stomach acid is needed to release vitamin B12 from food so it can be absorbed by the body. Ranitidine reduces stomach acid and is associated with decreased dietary vitamin B12 absorption. The vitamin B12 found in supplements is available to the body without the need for stomach acid. Lab tests can determine vitamin B12 levels.

Interactions with Other Compounds

Tobacco (Nicotiana species) A study of 18 healthy people found smoking decreased the acid blocking effects of Ranitidine.

Cisapride Also indexed as: Propulsid®

Interactions with Foods and Other Compounds

Alcohol Alcohol consumption interferes with Cisapride therapy.

Tobacco Smoking interferes with Cisapride therapy.

© Vicki Martin, Nutrition and Herbal Technical Consultant, Healtheries of New Zealand Limited. Used with permission.

  • http://www.jpeds.com/article/S0022-3476%2813%2901596-5/abstract?elsca1=etoc&elsca2=email&elsca3=0022-3476_201405_164_5&elsca4=pediatrics

    The Journal of Pediatrics, Volume 164, Issue 5, Pages 959-960, May 2014, Authors:William Tarnow-Mordi, BA, MBChB, DCH, FRCPCH; Roger F. Soll, MD

  • Hello - wondering if you can help, my now 5 year old had silent reflux, my 5 month old also has reflux, I saw a specialist in Auckland for my first child but cannot for the life of my remember his name - do you have a list of specialists in Auckland? Many thanks Misty

  • Hi :) just starting my five month old on solids , any foods worse or better for reflux sufferers ? She is quite constipated from losec and gaviscon so also foods that aren't constipating

  • We only have six members in our Hawkes Bay GRSNNZ Local Support Network on Facebook. If you are coping with reflux and living in this area, we would love you to join us. http://www.reflux.cryingoverspiltmilk.co.nz/grsnnz-membership-confidentiality-agreement-form/

    Gastric Reflux Support Network NZ for Parents of Infants & Children Charitable Trust Membership & Confidentiality Agreement Form / Newsletter Admin PageFirst NameLast nameEmailStreet AddressCity/TownAreaPostcodeDo you live in NZ?Country and Area if not NZHome Phone (include area code)Partner's NameE...

  • A large randomized controlled trial has shown benefits of probiotic treatment in an unselected general population of neonates.

  • hi there, im desperate for help. my wee girl is 5 weeks old and has always been unsettled from birth. At first she was constipated and in pain so paed put her on pepti junior and after no improvement added lactulose syrup for bowels. She has a bowel motion now only every 5-6 days so not ideal. over the passed few days she has got alot worse, fussing at feeds, acidy smelling breath, after finishing bottles she squirms in pain, cramps up like a banana, screams/cries etc. she doesnt spill ever and winds pretty well. Clearly something is still not right but have seen 3 paeds and all havent considered silent reflux?? i feel silly going back again but i know they are missing something, could it be reflux?? thanks Nicole

  • I have been reading your website, thank you, it's helped me a lot. 5 weeks with a very unhappy baby is extremely difficult.

  • Do you live in Northland, New Zealand and have a child with gastric reflux? We would love you to become a member of the Gastric Reflux Support Network NZ and join our latest Private Facebook Group - for the Northland GRSNNZ Local Support Network. We currently have five families who would be grateful to have contact with others in the Northland area and share their experiences. We have Local Support Networks throughout NZ and set up Private Facebook Groups as requested. We already have Yahoo Mailing Lists for each region, but many prefer Facebook. To join complete a membership and confidentiality form: http://www.reflux.cryingoverspiltmilk.co.nz/grsnnz.../ Membership is free, and this gives you opportunities to discuss gastric reflux related issues with others in a safe, private and confidential setting. You will also get access to our newsletters.

    Gastric Reflux Support Network NZ for Parents of Infants & Children Charitable Trust Membership & Confidentiality Agreement Form / Newsletter Admin PageFirst NameLast nameEmailStreet AddressCity/TownAreaPostcodeDo you live in NZ?Country and Area if not NZHome Phone (include area code)Partner's NameE...

  • Hi there, I was on your website reading that doctors should prescribe the Losec granules instead of the suspension. Does this apply for 2 month old babies as well?

  • I am hijacking this photo. #gastricreflux

  • Hi, I am interested in people's opinion on advice from a dietician re my 13 month son who has reflux and lower GI issues, both currently well managed. I have posted before: he's on a restricted diet - no dairy, soy, gluten as well as a random no tomato/potato (latter done by me without paed knowledge following nasty flare up). He is still bf and not a great solids eater - picky, limited finger foods only, no mush. He is small (prem, lbw) but not at all underweight for size. He is on iron supplement (formerly anaemic) and trying to wean off losec. Dietician wants us a) to go on to neocate advanced and b) to reintroduce gluten. Neither of these sit well with me. I ate non-GF oats and small amount non-GF pasta yesterday - now I have an unsettled boy stretching and groaning after a month of calm. Coincidence?? Re neocate - is it really necessary to give him this or can I find the iron and vitamin boost elsewhere? He hates the taste and doesn't eat porridge/mash/stewed fruit to mix it into. The dietician really p***ed me off for her manner and lack of knowledge of son's history (in spite of having met before) and I don't trust her judgment. Thoughts? Sorry long post. Thank you for reading.

  • https://www.youtube.com/watch?v=qTHhWf_hGJI

    Pyrosis RGO mécanisme